The victim was pronounced dead at the scene by a physician assistant from the Office of the Suffolk County Medical Examiner, police said.
Detectives ask anyone with information about the crash to contact the Third Squad at 631-854-8352.
The driver of the Toyota, Sabrina Cadogan, 36, of Central Islip, was taken into custody and charged with aggravated unlicensed operation for driving with a suspended license, police said.
A man was killed early Sunday morning while walking on a street in Central Islip, Suffolk County police said.
The victim, 30, whose identity was not immediately available, was walking on East Suffolk Avenue near Powell Avenue at about 2:20 a.m. when he was struck by a 2007 Toyota Prius traveling east, police say.
The vehicle was impounded for a safety check and the investigation is continuing, police said.