Campaigners against the tolls intend to hold demonstrations at Runcorn Town Hall and in Widnes on Sunday afternoon.
The government said tolls would be dropped once the costs are paid but campaigners said the charges will hit residents and local businesses.
Davina Morrell, a single mother who works in Liverpool, said: #8220;I#8217;m going to have to pay £700 a year to travel over the bridge. It#8217;s an awful lot of money when I#8217;m only a nurse.#8221;
The 1.5mi (2.2km) link forms the centrepiece in a project of improvements on a 9.2km route in the borough of Halton.