Few details about the incident were released Sunday morning. The shooting happened about 12:30 a.m. near the intersection of East 79th Street and St. Clair Avenue, Cleveland police spokesman Det. Reginald Lanton said.
The shooting death marks the 72nd homicide in Cleveland in 2017.
The male victim was struck in the chest by gunfire, Lanton said. He was taken to University Hospitals, where he died.
The victim will be identified by the Cuyahoga County Medical Examiner once his family is notified.