A 24-year-old man, from Dingle, was arrested on suspicion of causing death by dangerous driving.
Mossley Hill Drive remains closed in both directions between its junctions with Greenbank Drive and Croxteth Drive.
Merseyside Police have named the 16-year-old boy who died following a collision on Mossley Hill Drive on Monday, as Thomas Mark Edwards from Wavertree.
Anyone with information on this incident can call MSOC Roads Policing Officers on 0151 777 5747. Alternatively, call the 101 number or Crimestoppers, anonymously, on 0800 555 111.