The visitors#8217; advantage was subsequently doubled 22 minutes later by a wonderful Jemerson overhead kick, before Falcao added his second in the 37th minute via a curling effort from the edge of the box that may or may not have taken a slight deflection off Cedric Yambere.
Nine days on from Mbappe limping off in the 3-2 victory over Toulouse, and amid considerable speculation linking him with a move to Paris St Germain, the 18-year-old was named as a substitute for this contest by boss Leonardo Jardim.
Falcao then wrapped up his treble with a powerful header six minutes after the break.
And he remained unused as fellow forward Falcao took centre stage at the Stade Gaston Gerard.
He was then unable to keep out a penalty from Dimitri Lienard in the 82nd minute and an 88th-minute strike from Jeremy Grimm.